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Background: Physical train has been lengthy acknowledged for its therapeutic results on depressive disorders, however the underlying mechanisms stay largely unknown. In the examine, we investigated whether the bodily train by voluntary wheel working (VWR) alters depression-like behaviors and its affect on brain Blood Vitals oxygen stage-dependent (Bold) alerts in mice. Ex. The variations in purposeful mind adjustments had been decided by Bold functional magnetic resonance imaging (fMRI). Results: The results confirmed that VWR train significantly reversed the CUMS-induced behavioral abnormalities. Base on the fMRI amplitude of low-frequency fluctuation (ALFF) evaluation, we found that VWR train might restore the CUMS-induced extreme Bold activation in parts of limbic system, such as cortex, hippocampus and corpus callosum. Furthermore, CUMS-induced Bold suppressive areas had been also partially attenuated by VWR train, resembling amygdala, cerebellum anterior lobe, thalamus, midbrain, and pontine. Most of these areas are concerned in temper-regulating circuit, suggesting dysfunction of the circuit in CUMS model of depression, and VWR train may modify the mood-regulating circuit. |
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發表於 2025-8-9 15:19:15
