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Issue date 2021 May. To realize extremely accelerated sub-millimeter resolution T2-weighted useful MRI at 7T by developing a three-dimensional gradient and spin echo imaging (GRASE) with internal-quantity choice and variable flip angles (VFA). GRASE imaging has disadvantages in that 1) ok-house modulation causes T2 blurring by limiting the variety of slices and 2) a VFA scheme leads to partial success with substantial SNR loss. On this work, accelerated GRASE with controlled T2 blurring is developed to improve a degree unfold operate (PSF) and temporal sign-to-noise ratio (tSNR) with numerous slices. Numerical and experimental studies have been carried out to validate the effectiveness of the proposed method over common and VFA GRASE (R- and V-GRASE). The proposed methodology, while achieving 0.8mm isotropic decision, functional MRI in comparison with R- and V-GRASE improves the spatial extent of the excited volume as much as 36 slices with 52% to 68% full width at half maximum (FWHM) discount in PSF but roughly 2- to 3-fold mean tSNR improvement, thus leading to higher Bold activations.
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