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One promising method for mapping CMRO2 is dual-calibrated functional MRI (dc-fMRI). This technique exploits the Fick Principle to mix estimates of resting CBF from ASL, and resting OEF derived from Bold-ASL measurements throughout arterial O2 and CO2 modulations. Multiple fuel modulations are required to decouple OEF and deoxyhemoglobin-delicate blood quantity. We suggest an alternative single gasoline calibrated fMRI framework, integrating a mannequin of oxygen transport, that hyperlinks blood volume and CBF to OEF and creates a mapping between the maximum Bold signal, CBF, and OEF (and CMRO2). Simulations demonstrated the strategy's viability within mitochondrial oxygen pressure, PmO2, and imply capillary transit time physiological ranges. A dc-fMRI experiment, performed on 20 healthy subjects utilizing alternating O2 and CO2 challenges, was used to validate the approach. The validation conveyed expected estimates of model parameters (e.g., low PmO2), with stable OEF maps (gray matter, GM, OEF Standard Deviation≈0.13). 0.025 respectively). The simplified calibrated fMRI method utilizing hypercapnia holds promise for clinical software.
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