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Three totally different ranges of hyperchloremia had been induced in wholesome Friesian calves to check the effects of chloride on blood oxygen transport. By infusion, the calves received either 5 ml/kg of 0.9% NaCl (low-level hyperchloremia; group A), 5 ml/kg of 7.5% NaCl (average hyperchloremia; group B), or 7.5 ml/kg of 7.5% NaCl (high-stage hyperchloremia; group C). Blood was sampled from the jugular vein and the brachial artery. Chloride concentration, hemoglobin content, arterial and venous pH, PCO2, and PO2 had been decided. At each time level (0, 15, 30, 60, and a hundred and twenty min), the entire blood oxygen equilibrium curve (OEC) was measured below normal situations. In teams B and C, hyperchloremia was accompanied by a sustained rightward shift of the OEC, as indicated by the significant increase in the standard PO2 at 50% hemoglobin saturation. Infusion of hypertonic saline additionally induced relative acidosis. The arterial and venous OEC were calculated, with body temperature, pH, and PCO2 values in arterial and venous blood taken into consideration. A hundred ml of bovine blood (OEF vol%) have been calculated from the arterial and venous OEC combined with the PO2 and hemoglobin concentration. The chloride-induced rightward shift of the OEC was strengthened by the relative acidosis, however the altered PO2 values combined with the lower hemoglobin concentration explained the absence of any significant distinction in OEF (% and vol%). We conclude that infusion of hypertonic saline induces hyperchloremia and acidemia, which can clarify the OEC rightward shift observed in arterial and peripheral venous blood.
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